PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Tim Reluga, Carina Curto.

Title:Modeling metastasis at the molecular level: Network modeling of the epithelial-to-mesenchymal transition (reschedulaled)
Seminar:Theoretical Biology Seminar
Speaker: Jorge Gómez Tejeda Zañudo, Penn State Physics Department
Abstract:
Epithelial-to-mesenchymal transition (or EMT) is a developmental and wound-healing process hijacked by cancer cells that allows them to acquire an invasive phenotype, migrate from the primary tumor, and spread to other parts of the body. The molecular network regulating EMT is very intricate and involves the cooperation and cross-talk between multiple signaling pathways and transcriptional, translational and post-translational regulation of key transcription factors. To better understand cellular states in the EMT transition, we built and analyzed an EMT signaling model. Our analysis revealed TGFβ signaling, together with Wnt and Sonic Hedgehog pathways can drive the mesenchymal phenotype. Using our EMT network model, we investigate potential EMT-suppressing interventions by identifying all possible single and double target interventions that block or attenuate TGFβ-driven EMT. Surprisingly, we find that all non-trivial interventions are combinatorial and involve the inhibition of SMAD. Further, we analyzed the SMAD-perturbed EMT network and discovered a new set of cellular steady-states, intermediate to epithelial and mesenchymal steady states. These cellular steady-states support the hypothesized existence of hybrid epithelial-mesenchymal states potentially important in cancer treatment.

Room Reservation Information

Room Number:MB106
Date:03 / 01 / 2016
Time:01:30pm - 02:20pm