PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Tim Reluga, Carina Curto.

Title:Stochastic modeling of carcinogenesis
Seminar:Theoretical Biology Seminar
Speaker:Rafael Meza, University of Michigan
(Host: Jessica Conway)
Carcinogenesis is the transformation of normal cells into cancer cells. This process has been shown to be of a multistage nature, with stem cells that go through a series of (stochastic) genetic and epigenetic changes that eventually lead to a malignancy. Since the origins of the multistage theory in the 1950s, mathematical modeling has played a prominent role in the investigation of the mechanisms of carcinogenesis. In particular, two stochastic (mechanistic) models, the Armitage-Doll and the two-stage clonal expansion (TSCE) model, have been widely used in the past for cancer risk assessment and for the analysis of cancer population and experimental data. In this talk, I will introduce some of the biological and mathematical concepts behind the theory of multistage carcinogenesis, and discuss in detail the use of these models in cancer epidemiology. Recent applications of multistage models in lung and colon cancer will be reviewed.

Room Reservation Information

Room Number:MB106
Date:03 / 03 / 2015
Time:01:00pm - 02:00pm