PSU Mark
Eberly College of Science Mathematics Department

Meeting Details

For more information about this meeting, contact Carina Curto.

Title:Multiscale modeling of the innate immune to Aspergillus fumigatus in the lung
Seminar:Mathematical Biology Colloquium
Speaker:Reinhard Laubenbacher, University of Connecticut Health Center
(Host: Vladimir Itskov)
Abstract:
Aspergillus fumigatus is a ubiquitous fungus that causes severe respiratory disease in the growing population of patients with a compromised immune system, such as chemotherapy or organ transplant patients. Part of the innate immune response in the case of exposure to fungal spores are mechanisms that aim to restrict access to iron, an important metabolite for fungal growth. Thus, a "battle for iron" ensues between the fungus and the host. In order to exploit this battle in the search for new, host-centered therapeutics, multiscale mathematical modeling can be very helpful as a virtual laboratory, incorporating the tissue and molecular scales. This talk will discuss a model that combines an agent-based approach at the tissue-level with a generalized Boolean network model framework at the molecular level. Such models can be analyzed using methods from algebra and algebraic geometry. The talk will also discuss approaches to optimal control in this context.

Room Reservation Information

Room Number:MB106
Date:02 / 24 / 2015
Time:01:00pm - 02:00pm